Sexual dysfunction can be the result of a general medical condition or a urogenital one. It can also have psychological factors or be the result of psychiatric or non-psychiatric medications.

Pharmacologic agents associated in male sexual dysfunction include psychiatric drugs such as Lithium, the amphetamines, the SSRI’s and antipsychotics as well as anti-anxiety agents like Xanax. Anti-hypertensive drugs are often implicated. These include Clonidine, Methyldopa (Aldomet), Spironolactone (Aldactone), Hydrochlorothiazide and Guanethidine (Ismelin). Commonly abused substances associated with male sexual dysfunction include alcohol, barbiturates, cannabis, cocaine, heroin, methadone and morphine. Miscellaneous drugs include the antiparkinson agents, Digoxin (Lanoxin), Indomethacin (Indocin) and Propranolol (Inderal).

In female sexual dysfunction, endocrine disorders such as hypothyroidism, diabetes mellitus and primary hyperprolactinemia can have a negative effect. Antihypertensive medications, CNS stimulants and SSRI’s can also have a negative impact. In other situations, sexual dysfunction is substance induced.